1948 – Born in Kansas City, Missouri on the 28th of March.
1976 – She went to the Eugene O’Neill National Playwrights Conference and played leading roles in Amlin Gray’s "Pirates" and Christopher Durang’s "A History of the American Film." Shortly after that, she left Arena Stage, and performed more in New York City.
1980 – She made her film debut, but didn’t make a name for herself until her performance as Emma, a prostitute during the Great Depression, in Woody Allen’s The Purple Rose of Cairo.
1986 – Won an Oscar for Best Supporting Actress, in Hannah and Her Sisters.
1987-1988 – She followed her Academy Award success with performances in The Lost Boys and Bright Lights, Big City.
1990 – Wiest starred in Edward Scissorhands.
1994 – She returned to Woody Allen for Bullets Over Broadway, a comedy set in 1920s New York City, winning her second Best Supporting Actress Oscar for her portrayal of Helen Sinclair, a boozy, glamorous, and neurotic star of the stage.
1998-2000 – She has recently appeared in the film Practical Magic and the television mini-series The 10th Kingdom.
2002 – She portrayed Nora Lewin in the long-running NBC crime drama Law and Order.
2003 – She acted on Broadway with Al Pacino and Marisa Tomei in Oscar Wilde’s "Salome.
2005 – She starred in Kathleen Tolan’s "Memory House," and then at Lincoln Center in the late Wendy Wasserstein’s final play "Third," directed by Daniel Sullivan.