1963 – Born in Fairfield on the 19th of November.
1979 – She graduated from Bethel High School.
1981 – Her first role in a feature film, Rich and Famous.
1982-1984 – She played Betsy Stewart in the daytime drama As the World Turns.
1989 – Her first full blown hit in a leading role was the romantic comedy When Harry Met Sally.
1991 – She married actor Dennis Quaid on Valentine’s Day.
1992 – On the 24th of April, Quaid and Ryan have one child together, Jack Henry.
1994 – Won the Harvard Hasty Pudding Award as "Woman of the Year".
2001 – They got divorced on the 16th of July.
2003 – She broke away from her usual roles and starred in In the Cut, an erotic crime thriller.
2006 – She brought her newly adopted daughter, one-year-old Daisy True, home from China.