1493 - He began his career of exploration as part of Christopher Columbus' second expedition to the New World.
1502 - He was in the West Indies as a captain serving under Nicolás de Ovando, governor of Hispaniola.
1508-1509 - Explored and settled that island, founding the colony's oldest settlement, Caparra, near what is now San Juan.
1513 - He led a privately outfitted expedition from Puerto Rico in March and in April of that year landed on the coast of Florida near the site of modern St. Augustine.
1514 - He then returned to Puerto Rico and thence to Spain, where he secured the title in of military governor of Bimini and Florida with permission to colonize those regions.
1521 - He sailed again for Florida with two ships and 200 men, landing near Charlotte Harbor.
1521 - He died after being returned to Cuba. Puerto Rico's third largest city, Ponce, is named in his honour.