1951 - He was an indifferent student in high school and in the law school of Kabul University, quickly gained a reputation as an orator and activist in the university’s student union.
1965 - On the 1st of January, the People's Democratic Party of Afghanistan was founded in Kabul, with Karmal serving as one of its twenty-eight founding members in its founding congress.
- He was elected and served in the quasi-democratic National Assembly of Afghanistan during the Constitutional Monarchy of King Zahir Shah.
1967 - Karmal became the leader of the more moderate Parcham faction.
1978 - Afghan ambassador to Czechoslovakia.
1979 - The third President of Afghanistan.
- Prime minister of Afghanistan.
1986 - He was unable to consolidate his power, he was replaced by Dr. Mohammad Najibullah.
1989 - He left Afghanistan for Moscow, but returned to Kabul.
1996 - Died in Moscow's Central Clinical Hospital from liver cancer on the 3rd of December.