1769 - Born in Little Britain, New York on the 2nd of March.
- He was educated at what is now Columbia University.
- He became the secretary to his uncle, George Clinton.
1797-1802 - DeWitt Clinton was a member of the New York state legislature.
- He then stepped up to membership in the United States Senate.
1803 - He resigned his Senate seat, to become the Mayor of New York City.
1804-1815 - He served as Mayor.
- Clinton also held office as State Senator.
- Lieutenant Governor.
- Clinton ran for President of the United States as candidate of the Federalists and anti-war Democratic Republicans who were of the anti-war Fusion Party, but was defeated by James Madison.
1817-1823 - Clinton became the governor of New York.
- He persuaded the state lawmakers to provide 7 million dollars for the construction of a Canal 363 miles long, 40 feet wide, and four feet deep.
1825 - When the Erie Canal was finished, Governor Clinton opened it, sailing in the packet boat Seneca Chief along the Canal into Buffalo.
1828 - Died on the 11th of February at the age of 59 and was interred in the Green-Wood Cemetery in Brooklyn, New York.