1964 – He was bon on the 22nd day of July this year in Bogotá, Colombia. His father, Alberto Leguizamo, was a Puerto Rican realtor living in Colombia who met and married a young woman by the name of Luz.
1968 – His parents emigrated with them to the United States and settled down in the Jackson Heights section of Queens in New York City where Leguizamo received his primary and secondary education.
1983 – He was an extra in Madonna’s ‘Borderline’ video. He plays a friend of Madonna’s boyfriend.
1984 – He started out as a stand-up comic doing the New York nightclub circuit, this year; he made his TV debut with a small part in Miami Vice.
1985 – He appeared in the movie Mixed Blood.
1989 – He did “Casualties of War”.
1991 – He did “Hangin’ with the Homeboys”. He also wrote and took part in the Off-Broadway production Mambo Mouth, where he played seven different characters. Mambo Mouth won an Obie Award and an Outer Critics Award. He was listed as one of 12 "Promising New Actors of 1991" in "John Willis’ Screen Worlds Vol. 43".
1993 – He made “Night Owl”. He also wrote and participated in Spic-O-Rama, where he made fun of the stereotyping of Latinos in the U.S.. The production won a Drama Desk Award and four Cable ACE Awards.
2000 – He played two genies in the Emmy Award winning miniseries Arabian Nights. Leguizamo has participated in over 53 films, including The Alibi where he will play the role of "Hannibal" and which is in the post-production stages as of 2005.
2003 – He married Justine Maurer this year.
2005 – During this year until 2006 television season, he joined the cast of the show ER, playing Dr. Victor Clemente, a new attending that is keen on introducing the staff of County General to better ways of treating patients and cutting-edge technology.
2006 – His memoir, Pimps, Hos, Playa Hatas and All the Rest of My Hollywood Friends: A Life was released. During an interview on Late Night with Conan O’Brien, Leguizamo stated that his memoir was very frank about odd experiences involving other celebrities and co-stars he had worked with