1955 – She was born the 21st day of December this year in Milwaukee, Wisconsin, USA.
1992 – Kaczmarek married West Wing actor Bradley Whitford on the 15th day of August this year. They live in Los Angeles with their three children.
1998 – She has also appeared in several movies, including this year’s film Pleasantville, as Tobey Maguire and Reese Witherspoon’s "real-world" mother.
2000 – In this year, she was cast to play Lois, in the FOX mid-season replacement Malcolm in the Middle. She was nominated seven times for an Emmy for her performance on show. She also earned three Golden Globe nominations and two Screen Actors Guild Awards nominations, was honored with a Television Critics Association Award in this year and 2001.
2001 – This year, she was awarded an American Comedy Award and a Family Television Award.
2004 – Kaczmarek underwent a hip replacement in April this year, due to chronic arthritis. She recovered quickly, and used an X-ray of her new hip for her Emmy campaign the following summer, advertising herself as "the only Emmy nominee with an artificial hip (except for Anthony LaPaglia)."
2006 – She and Malcolm in the Middle co-star Erik Per Sullivan contributed the afterword for the children’s book Together, that shows the importance of livestock in the world, and was inspired by the mission of the nonprofit charitable organization Heifer International.