535 - Heraclitus was born.
- Diogenes also tells us that he deposited his book as a dedication in the great temple of Artemis, the Artemesium, one of the largest temples of the 6th century BCE.
- He disagreed with Thales, Anaximander, and Pythagoras about the nature of the ultimate substance, and instead claimed that the nature of everything is change itself.
475 - his eventual death from illness, including his supposed attempt to stave off death using dung and ignoring doctors.
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- "Nothing endures but change."
- "To God all things are beautiful, good, and right; human beings, on the other hand, deem some things right and others wrong. It would not be better if things happened to people just as they wish."
- "You can never step into the same river; for new waters are always flowing on to you."
- "Man is most nearly himself when he achieves the seriousness of a child at play."
- "Opposition brings concord. Out of discord comes the fairest harmony."