1856 – Born on the 21st of July in Waterloo, New York. She was the first professional woman architect in the United States.
1876 – She took a position as a draftsman in the Buffalo, New York, architectural firm of Richard A. Waite.
1881 – In October, she opened her own architectural office in partnership with Robert A. Bethune, whom she married in December.
1885 – She joined the Western Association of Architects, of which she later served a term as vice president.
1886 – She helped organize the Buffalo Society of Architects, it later became the Buffalo chapter of the American Institute of Architects.
1888 – In April, she became the first woman elected to membership in the American Institute of Architects, and the next year she became the first woman fellow of the institute.
1904 – Designed hotels, apartment houses, churches, factories, and banks, many of them in the Romanesque Revival style popular in the late 19th century. Among their major commissions were Lockport High School, the East Buffalo Live Stock Exchange, and the Hotel Lafayette in Buffalo.
1913 – She died on the 18th of December in Buffalo, New York.