1968 – She was born on the 8th day of April this year Chicago, Illinois.
1986 – At the age of eighteen she got her start in show business in Pretty Smart. Later, she gained attention for her starring role in A Nightmare on Elm Street 3: Dream Warriors, playing Kristen Parker.
1991 – She won a Cable ACE Award for her portrayal of a deaf epileptic in Wildflower.
1995 – She married Nicolas Cage whom she would later co-star with in Bringing Out the Dead in 1999.
2000 – Cage filed a divorce this year.
2002 – She and actor Thomas Jane became engaged in this year.
2005 – She began starring in her first television series, NBC’s Medium. Now in its 3rd season, the success of Medium has made Arquette a household name. She won an Emmy Award for Outstanding Lead Actress for her role as a psychic on NBC’s Medium.
2006 – She was married to Thomas Jane on June 25 of this year at the Palazzo Contarini in Venice, Italy.
2007 – She was again nominated for a Golden Globe Award for Medium